Interações medicamentosas
Insulin degludec-insulin aspart + Mecasermin
Gravidade: Grave
Insulin degludec-insulin aspart and Mecasermin: major interaction.
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Resumo
Mecasermin is recombinant IGF-1 and has insulin-like glucose-lowering activity, so combining it with insulin can cause additive and sometimes severe hypoglycemia.
O que esta interação significa em palavras simples
Insulin degludec-insulin aspart and Mecasermin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin degludec-insulin aspart belongs to Endocrine; Mecasermin belongs to Endocrine.
Por que acontece
Additive pharmacodynamic effect: IGF-1 acts on insulin receptors and IGF-1 receptors to lower blood glucose.
O que fazer
Give mecasermin with or shortly after a meal and monitor blood glucose closely. Reduce the insulin dose as needed.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Insulin degludec-insulin aspart
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- Ethanol + Insulin degludec-insulin aspart Grave
- Insulin degludec-insulin aspart + Pioglitazone Grave
- Insulin degludec-insulin aspart + Pramlintide Grave
Outras interações de Mecasermin
Perguntas frequentes
Can I take Insulin degludec-insulin aspart with Mecasermin?
MediHelp rates the interaction as major. Insulin degludec-insulin aspart and Mecasermin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mecasermin is recombinant IGF-1 and has insulin-like glucose-lowering activity, so combining it with insulin can cause additive and sometimes severe hypoglycemia.
How serious is the interaction between Insulin degludec-insulin aspart and Mecasermin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give mecasermin with or shortly after a meal and monitor blood glucose closely. Reduce the insulin dose as needed.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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