Interações medicamentosas
Alpelisib + Chlorpropamide
Gravidade: Moderada
Alpelisib and Chlorpropamide: moderate interaction.
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Resumo
Alpelisib may induce CYP2C9, which could lower exposure to CYP2C9 substrates and weaken their effect. However, alpelisib itself causes hyperglycemia, so glycemic control may worsen with chlorpropamide through both mechanisms.
O que esta interação significa em palavras simples
Alpelisib and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alpelisib belongs to Oncology; Chlorpropamide belongs to Endocrine.
Por que acontece
Alpelisib may induce CYP2C9 and also inhibits PI3K signaling, causing hyperglycemia that opposes the sulfonylurea.
O que fazer
Monitor blood glucose closely during alpelisib treatment. Increase the antidiabetic regimen as needed.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Chlorpropamide
Outras interações de Alpelisib
- Alpelisib + Carbamazepine Grave
- Alpelisib + Phenytoin Grave
- Alpelisib + Secobarbital Grave
- Alpelisib + Apalutamide Moderada
- Alpelisib + Bosentan Moderada
- Alpelisib + Cyclosporin Moderada
Perguntas frequentes
Can I take Alpelisib with Chlorpropamide?
MediHelp rates the interaction as moderate. Alpelisib and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Alpelisib may induce CYP2C9, which could lower exposure to CYP2C9 substrates and weaken their effect. However, alpelisib itself causes hyperglycemia, so glycemic control may worsen with chlorpropamide through both mechanisms.
How serious is the interaction between Alpelisib and Chlorpropamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during alpelisib treatment. Increase the antidiabetic regimen as needed.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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