Interações medicamentosas
Alpelisib + Cyclosporin
Gravidade: Moderada
Alpelisib and Cyclosporin: moderate interaction.
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Resumo
Cyclosporine may inhibit BCRP and raise alpelisib concentrations, which could increase hyperglycemia, rash and diarrhea.
O que esta interação significa em palavras simples
Alpelisib and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alpelisib belongs to Oncology; Cyclosporin belongs to Miscellaneous.
Por que acontece
Inhibition of BCRP-mediated efflux of alpelisib increases its systemic exposure.
O que fazer
Prefer an alternative immunosuppressant if possible. If the combination is needed, monitor blood glucose and for alpelisib adverse reactions and adjust alpelisib dose as needed.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicada
- Aliskiren + Cyclosporin Contraindicada
- Bcg vaccine live + Cyclosporin Contraindicada
- Bosentan + Cyclosporin Contraindicada
- Cidofovir + Cyclosporin Contraindicada
- Cyclosporin + Dengue vaccine Contraindicada
Outras interações de Alpelisib
- Alpelisib + Carbamazepine Grave
- Alpelisib + Phenytoin Grave
- Alpelisib + Secobarbital Grave
- Alpelisib + Apalutamide Moderada
- Alpelisib + Bosentan Moderada
- Alpelisib + Chlorpropamide Moderada
Perguntas frequentes
Can I take Alpelisib with Cyclosporin?
MediHelp rates the interaction as moderate. Alpelisib and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may inhibit BCRP and raise alpelisib concentrations, which could increase hyperglycemia, rash and diarrhea.
How serious is the interaction between Alpelisib and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative immunosuppressant if possible. If the combination is needed, monitor blood glucose and for alpelisib adverse reactions and adjust alpelisib dose as needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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