Interações medicamentosas
Alprazolam + Fentanyl
Gravidade: Grave
Alprazolam and Fentanyl: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Concurrent opioids and benzodiazepines can cause profound sedation, respiratory depression, coma and death. Regulators carry boxed warnings for this combination.
O que esta interação significa em palavras simples
Alprazolam and Fentanyl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Alprazolam belongs to Central Nervous System; Fentanyl belongs to Musculoskeletal.
Por que acontece
Additive CNS and respiratory depression via opioid receptor and GABA-A receptor activity.
O que fazer
Reserve the combination for patients with no alternatives, using the lowest doses and shortest duration. Monitor respiratory rate and sedation closely.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
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Outras interações de Fentanyl
- Alvimopan + Fentanyl Contraindicada
- Fentanyl + Isocarboxazid Contraindicada
- Fentanyl + Olanzapine / samidorphan Contraindicada
- Fentanyl + Phenelzine Contraindicada
- Fentanyl + Tranylcypromine Contraindicada
- Alfentanil + Fentanyl Grave
Outras interações de Alprazolam
- Alprazolam + Calcium / magnesium / potassium / sodium oxybates Contraindicada
- Alprazolam + Itraconazole Contraindicada
- Alprazolam + Ketoconazole Contraindicada
- Alprazolam + Levoketoconazole Contraindicada
- Alprazolam + Sodium oxybate Contraindicada
- Alfentanil + Alprazolam Grave
Perguntas frequentes
Can I take Alprazolam with Fentanyl?
MediHelp rates the interaction as major. Alprazolam and Fentanyl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent opioids and benzodiazepines can cause profound sedation, respiratory depression, coma and death. Regulators carry boxed warnings for this combination.
How serious is the interaction between Alprazolam and Fentanyl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients with no alternatives, using the lowest doses and shortest duration. Monitor respiratory rate and sedation closely.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
