Interações medicamentosas
Fentanyl + Phenelzine
Gravidade: Contraindicada
Fentanyl and Phenelzine: contraindicated interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Phenelzine irreversibly blocks MAO-A and MAO-B, and fentanyl is a serotonergic opioid. Serotonin syndrome or an excitatory/depressive MAOI-opioid reaction (hypertension or profound respiratory depression) may result.
O que esta interação significa em palavras simples
Fentanyl and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fentanyl belongs to Musculoskeletal; Phenelzine belongs to Central Nervous System.
Por que acontece
MAO inhibition with serotonergic opioid effect
O que fazer
Avoid fentanyl within 14 days of an MAOI; if opioid is essential, use the lowest dose with close monitoring.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Para assinantes do Pro+
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- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
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Outras interações de Fentanyl
- Alvimopan + Fentanyl Contraindicada
- Fentanyl + Isocarboxazid Contraindicada
- Fentanyl + Olanzapine / samidorphan Contraindicada
- Fentanyl + Tranylcypromine Contraindicada
- Alfentanil + Fentanyl Grave
- Alprazolam + Fentanyl Grave
Outras interações de Phenelzine
- 5-HTP + Phenelzine Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amoxapine + Phenelzine Contraindicada
- Atomoxetine + Phenelzine Contraindicada
- Benzphetamine + Phenelzine Contraindicada
- Brimonidine + Phenelzine Contraindicada
Perguntas frequentes
Can I take Fentanyl with Phenelzine?
MediHelp rates the interaction as contraindicated. Fentanyl and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenelzine irreversibly blocks MAO-A and MAO-B, and fentanyl is a serotonergic opioid. Serotonin syndrome or an excitatory/depressive MAOI-opioid reaction (hypertension or profound respiratory depression) may result.
How serious is the interaction between Fentanyl and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid fentanyl within 14 days of an MAOI; if opioid is essential, use the lowest dose with close monitoring.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
