Interações medicamentosas
Alvimopan + Fentanyl
Gravidade: Contraindicada
Alvimopan and Fentanyl: contraindicated interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Alvimopan antagonises peripheral mu-opioid receptors, and patients who have recently taken opioids for more than 7 days are more sensitive to it. This can cause abdominal pain, nausea, vomiting and diarrhea. Short-term perioperative opioid exposure is not expected to cause a significant interaction.
O que esta interação significa em palavras simples
Alvimopan and Fentanyl are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Competitive antagonism of peripheral mu-opioid receptors by alvimopan.
O que fazer
Do not use alvimopan in patients who have had therapeutic opioid doses for more than 7 consecutive days before starting it. Short-term perioperative use is acceptable.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Fentanyl
- Fentanyl + Isocarboxazid Contraindicada
- Fentanyl + Olanzapine / samidorphan Contraindicada
- Fentanyl + Phenelzine Contraindicada
- Fentanyl + Tranylcypromine Contraindicada
- Alfentanil + Fentanyl Grave
- Alprazolam + Fentanyl Grave
Perguntas frequentes
Can I take Alvimopan with Fentanyl?
MediHelp rates the interaction as contraindicated. Alvimopan and Fentanyl are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Alvimopan antagonises peripheral mu-opioid receptors, and patients who have recently taken opioids for more than 7 days are more sensitive to it. This can cause abdominal pain, nausea, vomiting and diarrhea. Short-term perioperative opioid exposure is not expected to cause a significant interaction.
How serious is the interaction between Alvimopan and Fentanyl?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use alvimopan in patients who have had therapeutic opioid doses for more than 7 consecutive days before starting it. Short-term perioperative use is acceptable.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Fentanyl page.
Monografias completas, posologia e verificador de interações no app MediHelp
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