Interações medicamentosas
Amikacin + Cefpodoxime
Gravidade: Moderada
Amikacin and Cefpodoxime: moderate interaction.
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Resumo
Cephalosporins have been reported to add to aminoglycoside nephrotoxicity, though oral cefpodoxime has low direct renal toxicity. Risk is higher in patients with kidney impairment, older age, or dehydration.
O que esta interação significa em palavras simples
Amikacin and Cefpodoxime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Cefpodoxime belongs to Anti Bacterial.
Por que acontece
Possible additive renal tubular injury; cefpodoxime itself is rarely nephrotoxic.
O que fazer
Monitor serum creatinine and amikacin levels, and watch for hearing or vestibular symptoms. Adjust amikacin dosing to renal function.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cefpodoxime
- Aluminum hydroxide + Cefpodoxime Moderada
- Calcium carbonate + Cefpodoxime Moderada
- Calcium + Cefpodoxime Moderada
- Cefpodoxime + Cholera vaccine Moderada
- Cefpodoxime + Cimetidine Moderada
- Cefpodoxime + Didanosine Moderada
Outras interações de Amikacin
- Amikacin + Cidofovir Contraindicada
- Adefovir + Amikacin Grave
- Amikacin + Amphotericin b Grave
- Amikacin + Amphotericin b deoxycholate Grave
- Amikacin + Atracurium Grave
- Amikacin + Bacitracin Grave
Perguntas frequentes
Can I take Amikacin with Cefpodoxime?
MediHelp rates the interaction as moderate. Amikacin and Cefpodoxime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cephalosporins have been reported to add to aminoglycoside nephrotoxicity, though oral cefpodoxime has low direct renal toxicity. Risk is higher in patients with kidney impairment, older age, or dehydration.
How serious is the interaction between Amikacin and Cefpodoxime?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin levels, and watch for hearing or vestibular symptoms. Adjust amikacin dosing to renal function.
What other medicines interact with Cefpodoxime?
MediHelp also lists interactions of Cefpodoxime with, for example, Aluminum hydroxide, Calcium carbonate, Calcium. The full list is on the Cefpodoxime page.
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