Interações medicamentosas
Aluminum hydroxide + Cefpodoxime
Gravidade: Moderada
Aluminum hydroxide and Cefpodoxime: moderate interaction.
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Resumo
Antacids that raise gastric pH reduce the dissolution and absorption of cefpodoxime proxetil. This can lower peak concentrations and total exposure and may reduce antibacterial efficacy.
O que esta interação significa em palavras simples
Aluminum hydroxide and Cefpodoxime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Cefpodoxime belongs to Anti Bacterial.
Por que acontece
Higher gastric pH impairs dissolution of cefpodoxime proxetil, which depends on an acidic environment, and so reduces its absorption.
O que fazer
Give cefpodoxime at least 2 hours before or after the aluminum hydroxide antacid. If acid suppression is needed continuously, consider another cephalosporin or monitor clinical response.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Aluminum hydroxide
Outras interações de Cefpodoxime
- Amikacin + Cefpodoxime Moderada
- Calcium carbonate + Cefpodoxime Moderada
- Calcium + Cefpodoxime Moderada
- Cefpodoxime + Cholera vaccine Moderada
- Cefpodoxime + Cimetidine Moderada
- Cefpodoxime + Didanosine Moderada
Perguntas frequentes
Can I take Aluminum hydroxide with Cefpodoxime?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Cefpodoxime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antacids that raise gastric pH reduce the dissolution and absorption of cefpodoxime proxetil. This can lower peak concentrations and total exposure and may reduce antibacterial efficacy.
How serious is the interaction between Aluminum hydroxide and Cefpodoxime?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give cefpodoxime at least 2 hours before or after the aluminum hydroxide antacid. If acid suppression is needed continuously, consider another cephalosporin or monitor clinical response.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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