Interações medicamentosas
Amiloride + Amlodipine-olmesartan-hydrochlorothiazide
Gravidade: Grave
Amiloride and Amlodipine-olmesartan-hydrochlorothiazide: major interaction.
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Resumo
Olmesartan and amiloride both reduce potassium excretion and can cause hyperkalemia, which hydrochlorothiazide only partly offsets. The risk is highest with renal impairment, diabetes or older age.
O que esta interação significa em palavras simples
Amiloride and Amlodipine-olmesartan-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiloride belongs to Cardiovascular; Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular.
Por que acontece
Additive reduction of renal potassium excretion by angiotensin receptor blockade and ENaC inhibition, partly opposed by thiazide kaliuresis.
O que fazer
Monitor serum potassium and renal function soon after starting and periodically thereafter. Stop amiloride and avoid potassium supplements if hyperkalemia develops.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicada
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicada
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicada
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Grave
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Grave
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Grave
Outras interações de Amiloride
- Amiloride + Eplerenone Contraindicada
- Amiloride + Spironolactone Contraindicada
- Amiloride + Triamterene Contraindicada
- Aceclofenac + Amiloride Grave
- Acemetacin + Amiloride Grave
- Amiloride + Amlodipine-benazepril Grave
Perguntas frequentes
Can I take Amiloride with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp rates the interaction as major. Amiloride and Amlodipine-olmesartan-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Olmesartan and amiloride both reduce potassium excretion and can cause hyperkalemia, which hydrochlorothiazide only partly offsets. The risk is highest with renal impairment, diabetes or older age.
How serious is the interaction between Amiloride and Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function soon after starting and periodically thereafter. Stop amiloride and avoid potassium supplements if hyperkalemia develops.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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