Interações medicamentosas
Amisulpride + Lithium
Gravidade: Grave
Amisulpride and Lithium: major interaction.
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Resumo
Both drugs have been associated with QT prolongation, and amisulpride carries a dose-related risk of torsades de pointes. The combined risk is higher with electrolyte disturbance, bradycardia or renal impairment, which also raises lithium levels.
O que esta interação significa em palavras simples
Amisulpride and Lithium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Lithium belongs to Central Nervous System.
Por que acontece
Additive effects on cardiac repolarization leading to QT interval prolongation.
O que fazer
Avoid the combination when possible. If used, obtain a baseline and follow-up ECG, correct potassium and magnesium, and monitor lithium levels and renal function.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Lithium
- Lithium + Thioridazine Contraindicada
- Lithium + Vandetanib Contraindicada
- Aceclofenac + Lithium Grave
- Acemetacin + Lithium Grave
- Amlodipine-benazepril + Lithium Grave
- Amlodipine-hydrochlorothiazide-valsartan + Lithium Grave
Outras interações de Amisulpride
- Amiodarone + Amisulpride Contraindicada
- Amisulpride + Arsenic trioxide Contraindicada
- Amisulpride + Disopyramide Contraindicada
- Amisulpride + Dofetilide Contraindicada
- Amisulpride + Droperidol Contraindicada
- Amisulpride + Ibutilide Contraindicada
Perguntas frequentes
Can I take Amisulpride with Lithium?
MediHelp rates the interaction as major. Amisulpride and Lithium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs have been associated with QT prolongation, and amisulpride carries a dose-related risk of torsades de pointes. The combined risk is higher with electrolyte disturbance, bradycardia or renal impairment, which also raises lithium levels.
How serious is the interaction between Amisulpride and Lithium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible. If used, obtain a baseline and follow-up ECG, correct potassium and magnesium, and monitor lithium levels and renal function.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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