Interações medicamentosas
Amisulpride + Arsenic trioxide
Gravidade: Contraindicada
Amisulpride and Arsenic trioxide: contraindicated interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Arsenic trioxide markedly prolongs the QT interval and has been linked to torsades de pointes. Adding amisulpride, which also prolongs QTc, increases the risk of life-threatening arrhythmia.
O que esta interação significa em palavras simples
Amisulpride and Arsenic trioxide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amisulpride belongs to Central Nervous System; Arsenic trioxide belongs to Oncology.
Por que acontece
Additive prolongation of cardiac repolarization through effects on cardiac ion channels such as hERG.
O que fazer
Avoid concurrent use and choose an alternative antipsychotic or antiemetic with lower QT risk. If unavoidable, monitor ECG continuously and keep potassium and magnesium in the normal range.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Amisulpride e Arsenic trioxide, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Amisulpride
- Amiodarone + Amisulpride Contraindicada
- Amisulpride + Disopyramide Contraindicada
- Amisulpride + Dofetilide Contraindicada
- Amisulpride + Droperidol Contraindicada
- Amisulpride + Ibutilide Contraindicada
- Amisulpride + Pimozide Contraindicada
Outras interações de Arsenic trioxide
- Amiodarone + Arsenic trioxide Contraindicada
- Arsenic trioxide + Clomipramine Contraindicada
- Arsenic trioxide + Dronedarone Contraindicada
- Arsenic trioxide + Fluphenazine Contraindicada
- Arsenic trioxide + Gemifloxacin Contraindicada
- Arsenic trioxide + Hydroxychloroquine Contraindicada
Perguntas frequentes
Can I take Amisulpride with Arsenic trioxide?
MediHelp rates the interaction as contraindicated. Amisulpride and Arsenic trioxide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Arsenic trioxide markedly prolongs the QT interval and has been linked to torsades de pointes. Adding amisulpride, which also prolongs QTc, increases the risk of life-threatening arrhythmia.
How serious is the interaction between Amisulpride and Arsenic trioxide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose an alternative antipsychotic or antiemetic with lower QT risk. If unavoidable, monitor ECG continuously and keep potassium and magnesium in the normal range.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Disopyramide, Dofetilide. The full list is on the Amisulpride page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
