Interações medicamentosas
Amlodipine-hydrochlorothiazide-valsartan + Lithium
Gravidade: Grave
Amlodipine-hydrochlorothiazide-valsartan and Lithium: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Both valsartan and hydrochlorothiazide can reduce renal lithium clearance, raising serum lithium and risking toxicity such as tremor, ataxia, confusion and arrhythmias. The thiazide effect is particularly well documented and the risk is greater with volume depletion.
O que esta interação significa em palavras simples
Amlodipine-hydrochlorothiazide-valsartan and Lithium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Lithium belongs to Central Nervous System.
Por que acontece
Reduced renal lithium excretion due to increased proximal tubular sodium and lithium reabsorption from thiazide-induced volume contraction and angiotensin receptor blockade.
O que fazer
Avoid if possible; otherwise check lithium level within the first week after starting and after dose changes and reduce the lithium dose as needed. Educate the patient about toxicity symptoms and maintain hydration.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Amlodipine-hydrochlorothiazide-valsartan e Lithium, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicada
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicada
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicada
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Grave
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Grave
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Grave
Outras interações de Lithium
- Lithium + Thioridazine Contraindicada
- Lithium + Vandetanib Contraindicada
- Aceclofenac + Lithium Grave
- Acemetacin + Lithium Grave
- Amisulpride + Lithium Grave
- Amlodipine-benazepril + Lithium Grave
Perguntas frequentes
Can I take Amlodipine-hydrochlorothiazide-valsartan with Lithium?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Lithium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both valsartan and hydrochlorothiazide can reduce renal lithium clearance, raising serum lithium and risking toxicity such as tremor, ataxia, confusion and arrhythmias. The thiazide effect is particularly well documented and the risk is greater with volume depletion.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Lithium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise check lithium level within the first week after starting and after dose changes and reduce the lithium dose as needed. Educate the patient about toxicity symptoms and maintain hydration.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
