Interações medicamentosas
Amisulpride + Thioridazine
Gravidade: Contraindicada
Amisulpride and Thioridazine: contraindicated interaction.
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Resumo
Thioridazine and amisulpride each delay ventricular repolarisation, so using them together adds to the chance of marked QTc lengthening. This can precipitate torsades de pointes, particularly with hypokalaemia, bradycardia or structural heart disease.
O que esta interação significa em palavras simples
Amisulpride and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amisulpride belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Por que acontece
Additive QTc prolongation through hERG potassium channel blockade
O que fazer
Do not co-prescribe; choose an agent without QT liability. If one must continue, obtain ECG and electrolytes first.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Thioridazine
- Abiraterone + Thioridazine Contraindicada
- Adagrasib + Thioridazine Contraindicada
- Amiodarone + Thioridazine Contraindicada
- Amitriptyline + Thioridazine Contraindicada
- Amoxapine + Thioridazine Contraindicada
- Anagrelide + Thioridazine Contraindicada
Outras interações de Amisulpride
- Amiodarone + Amisulpride Contraindicada
- Amisulpride + Arsenic trioxide Contraindicada
- Amisulpride + Disopyramide Contraindicada
- Amisulpride + Dofetilide Contraindicada
- Amisulpride + Droperidol Contraindicada
- Amisulpride + Ibutilide Contraindicada
Perguntas frequentes
Can I take Amisulpride with Thioridazine?
MediHelp rates the interaction as contraindicated. Amisulpride and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine and amisulpride each delay ventricular repolarisation, so using them together adds to the chance of marked QTc lengthening. This can precipitate torsades de pointes, particularly with hypokalaemia, bradycardia or structural heart disease.
How serious is the interaction between Amisulpride and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-prescribe; choose an agent without QT liability. If one must continue, obtain ECG and electrolytes first.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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