Interações medicamentosas
Amoxapine + Thioridazine
Gravidade: Contraindicada
Amoxapine and Thioridazine: contraindicated interaction.
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Resumo
Both drugs can prolong the QT interval, and thioridazine carries a particularly high risk of torsades de pointes. Combining them also adds anticholinergic and sedative effects, and thioridazine can raise amoxapine levels.
O que esta interação significa em palavras simples
Amoxapine and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Additive QT prolongation, with thioridazine inhibiting CYP2D6 metabolism of amoxapine.
O que fazer
Avoid combining; choose an antidepressant with minimal QT effect. If previously combined, perform ECG and check electrolytes.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Thioridazine
- Abiraterone + Thioridazine Contraindicada
- Adagrasib + Thioridazine Contraindicada
- Amiodarone + Thioridazine Contraindicada
- Amisulpride + Thioridazine Contraindicada
- Amitriptyline + Thioridazine Contraindicada
- Anagrelide + Thioridazine Contraindicada
Perguntas frequentes
Can I take Amoxapine with Thioridazine?
MediHelp rates the interaction as contraindicated. Amoxapine and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can prolong the QT interval, and thioridazine carries a particularly high risk of torsades de pointes. Combining them also adds anticholinergic and sedative effects, and thioridazine can raise amoxapine levels.
How serious is the interaction between Amoxapine and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; choose an antidepressant with minimal QT effect. If previously combined, perform ECG and check electrolytes.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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