Interações medicamentosas
Amitriptyline + Bethanechol
Gravidade: Moderada
Amitriptyline and Bethanechol: moderate interaction.
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Resumo
Amitriptyline has strong anticholinergic activity that directly opposes the muscarinic effects of bethanechol. This can reduce bethanechol's benefit in urinary retention and may worsen retention caused by the antidepressant.
O que esta interação significa em palavras simples
Amitriptyline and Bethanechol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Bethanechol belongs to Gastrointestinal Tract.
Por que acontece
Pharmacodynamic antagonism between a muscarinic agonist and a muscarinic antagonist.
O que fazer
Monitor urinary symptoms and bethanechol response. Consider a less anticholinergic antidepressant if retention persists.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Bethanechol
- Bethanechol + Darifenacin Grave
- Bethanechol + Fesoterodine Grave
- Bethanechol + Oxybutynin Grave
- Bethanechol + Physostigmine Grave
- Amifampridine + Bethanechol Moderada
- Amoxapine + Bethanechol Moderada
Outras interações de Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicada
- Amitriptyline + Methylene blue Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amitriptyline + Pimozide Contraindicada
- Amitriptyline + Procarbazine Contraindicada
- Amitriptyline + Safinamide Contraindicada
Perguntas frequentes
Can I take Amitriptyline with Bethanechol?
MediHelp rates the interaction as moderate. Amitriptyline and Bethanechol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amitriptyline has strong anticholinergic activity that directly opposes the muscarinic effects of bethanechol. This can reduce bethanechol's benefit in urinary retention and may worsen retention caused by the antidepressant.
How serious is the interaction between Amitriptyline and Bethanechol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary symptoms and bethanechol response. Consider a less anticholinergic antidepressant if retention persists.
What other medicines interact with Bethanechol?
MediHelp also lists interactions of Bethanechol with, for example, Darifenacin, Fesoterodine, Oxybutynin. The full list is on the Bethanechol page.
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