Interações medicamentosas
Amitriptyline + Dacomitinib
Gravidade: Grave
Amitriptyline and Dacomitinib: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Dacomitinib is a strong CYP2D6 inhibitor and can substantially raise amitriptyline concentrations. This may increase anticholinergic effects, sedation, QT prolongation and arrhythmia risk.
O que esta interação significa em palavras simples
Amitriptyline and Dacomitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Dacomitinib belongs to Oncology.
Por que acontece
Dacomitinib inhibits CYP2D6, reducing the metabolism of amitriptyline and its active metabolite.
O que fazer
Avoid if possible or reduce the amitriptyline dose and monitor for toxicity. Check an ECG and consider tricyclic levels in higher-risk patients.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Amitriptyline e Dacomitinib, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicada
- Amitriptyline + Methylene blue Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amitriptyline + Pimozide Contraindicada
- Amitriptyline + Procarbazine Contraindicada
- Amitriptyline + Safinamide Contraindicada
Outras interações de Dacomitinib
- Dacomitinib + Thioridazine Contraindicada
- Atomoxetine + Dacomitinib Grave
- Brexpiprazole + Dacomitinib Grave
- Clomipramine + Dacomitinib Grave
- Dacomitinib + Desipramine Grave
- Dacomitinib + Dexlansoprazole Grave
Perguntas frequentes
Can I take Amitriptyline with Dacomitinib?
MediHelp rates the interaction as major. Amitriptyline and Dacomitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dacomitinib is a strong CYP2D6 inhibitor and can substantially raise amitriptyline concentrations. This may increase anticholinergic effects, sedation, QT prolongation and arrhythmia risk.
How serious is the interaction between Amitriptyline and Dacomitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible or reduce the amitriptyline dose and monitor for toxicity. Check an ECG and consider tricyclic levels in higher-risk patients.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
