Interações medicamentosas
Dacomitinib + Desipramine
Gravidade: Grave
Dacomitinib and Desipramine: major interaction.
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Resumo
Dacomitinib is a strong CYP2D6 inhibitor, and desipramine is cleared mainly via CYP2D6. Desipramine exposure can rise markedly, increasing the risk of anticholinergic effects, cardiac conduction abnormalities and arrhythmia.
O que esta interação significa em palavras simples
Dacomitinib and Desipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dacomitinib belongs to Oncology; Desipramine belongs to Central Nervous System.
Por que acontece
Dacomitinib inhibits CYP2D6, reducing the metabolism of desipramine.
O que fazer
Avoid the combination if possible. If used, reduce the desipramine dose guided by plasma levels and ECG monitoring, and watch for toxicity.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Desipramine
- Desipramine + Disopyramide Contraindicada
- Desipramine + Dofetilide Contraindicada
- Desipramine + Ibutilide Contraindicada
- Desipramine + Isocarboxazid Contraindicada
- Desipramine + Methylene blue Contraindicada
- Desipramine + Pentamidine Contraindicada
Outras interações de Dacomitinib
- Dacomitinib + Thioridazine Contraindicada
- Amitriptyline + Dacomitinib Grave
- Atomoxetine + Dacomitinib Grave
- Brexpiprazole + Dacomitinib Grave
- Clomipramine + Dacomitinib Grave
- Dacomitinib + Dexlansoprazole Grave
Perguntas frequentes
Can I take Dacomitinib with Desipramine?
MediHelp rates the interaction as major. Dacomitinib and Desipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dacomitinib is a strong CYP2D6 inhibitor, and desipramine is cleared mainly via CYP2D6. Desipramine exposure can rise markedly, increasing the risk of anticholinergic effects, cardiac conduction abnormalities and arrhythmia.
How serious is the interaction between Dacomitinib and Desipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If used, reduce the desipramine dose guided by plasma levels and ECG monitoring, and watch for toxicity.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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