Interações medicamentosas
Amitriptyline + Epinephrine
Gravidade: Grave
Amitriptyline and Epinephrine: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Tricyclics block norepinephrine reuptake and sensitise adrenergic receptors, so systemic epinephrine can cause exaggerated hypertension, tachycardia and arrhythmias. The effect is most important with parenteral or large doses, whereas small amounts in dental local anaesthetics carry less risk.
O que esta interação significa em palavras simples
Amitriptyline and Epinephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Epinephrine belongs to Endocrine.
Por que acontece
Tricyclic blockade of catecholamine reuptake potentiates pressor and arrhythmogenic responses to epinephrine.
O que fazer
Use the lowest effective epinephrine dose with continuous blood pressure and ECG monitoring when systemic use is needed. Limit epinephrine in local anaesthetics and avoid intravascular injection.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Amitriptyline e Epinephrine, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Outras interações de Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicada
- Amitriptyline + Methylene blue Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amitriptyline + Pimozide Contraindicada
- Amitriptyline + Procarbazine Contraindicada
- Amitriptyline + Safinamide Contraindicada
Outras interações de Epinephrine
- Epinephrine + Isocarboxazid Contraindicada
- Epinephrine + Phenelzine Contraindicada
- Epinephrine + Tranylcypromine Contraindicada
- Acebutolol + Epinephrine Grave
- Amoxapine + Epinephrine Grave
- Atenolol-chlorthalidone + Epinephrine Grave
Perguntas frequentes
Can I take Amitriptyline with Epinephrine?
MediHelp rates the interaction as major. Amitriptyline and Epinephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tricyclics block norepinephrine reuptake and sensitise adrenergic receptors, so systemic epinephrine can cause exaggerated hypertension, tachycardia and arrhythmias. The effect is most important with parenteral or large doses, whereas small amounts in dental local anaesthetics carry less risk.
How serious is the interaction between Amitriptyline and Epinephrine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective epinephrine dose with continuous blood pressure and ECG monitoring when systemic use is needed. Limit epinephrine in local anaesthetics and avoid intravascular injection.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
