Interações medicamentosas
Epinephrine + Tranylcypromine
Gravidade: Contraindicada
Epinephrine and Tranylcypromine: contraindicated interaction.
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Resumo
Epinephrine is partly cleared by MAO and COMT, and tranylcypromine inhibits monoamine oxidase, which prolongs and intensifies its pressor action. Hypertensive crisis and arrhythmia may follow, especially with systemic dosing.
O que esta interação significa em palavras simples
Epinephrine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Epinephrine belongs to Endocrine; Tranylcypromine belongs to Central Nervous System.
Por que acontece
MAO inhibition potentiating sympathomimetic effects
O que fazer
Avoid systemic epinephrine; if essential for anaphylaxis, use titrated doses with blood pressure and ECG monitoring.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicada
- Amitriptyline + Tranylcypromine Contraindicada
- Amoxapine + Tranylcypromine Contraindicada
- Atomoxetine + Tranylcypromine Contraindicada
- Benzphetamine + Tranylcypromine Contraindicada
- Brimonidine + Tranylcypromine Contraindicada
Outras interações de Epinephrine
- Epinephrine + Isocarboxazid Contraindicada
- Epinephrine + Phenelzine Contraindicada
- Acebutolol + Epinephrine Grave
- Amitriptyline + Epinephrine Grave
- Amoxapine + Epinephrine Grave
- Atenolol-chlorthalidone + Epinephrine Grave
Perguntas frequentes
Can I take Epinephrine with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Epinephrine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Epinephrine is partly cleared by MAO and COMT, and tranylcypromine inhibits monoamine oxidase, which prolongs and intensifies its pressor action. Hypertensive crisis and arrhythmia may follow, especially with systemic dosing.
How serious is the interaction between Epinephrine and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic epinephrine; if essential for anaphylaxis, use titrated doses with blood pressure and ECG monitoring.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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