Interações medicamentosas
Amitriptyline + Guanfacine
Gravidade: Moderada
Amitriptyline and Guanfacine: moderate interaction.
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Resumo
Tricyclics may blunt the antihypertensive effect of centrally acting alpha-2 agonists. Both drugs also cause sedation and may cause orthostatic hypotension or bradycardia.
O que esta interação significa em palavras simples
Amitriptyline and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amitriptyline belongs to Central Nervous System; Guanfacine belongs to Cardiovascular.
Por que acontece
Tricyclics may antagonize alpha-2 agonist action, and there is additive sedative and hypotensive pharmacodynamic effect.
O que fazer
Monitor blood pressure and heart rate and adjust guanfacine as required. Monitor for sedation and dizziness.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicada
- Amitriptyline + Methylene blue Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amitriptyline + Pimozide Contraindicada
- Amitriptyline + Procarbazine Contraindicada
- Amitriptyline + Safinamide Contraindicada
Outras interações de Guanfacine
- Clonidine + Guanfacine Grave
- Guanfacine + Lofexidine Grave
- Aldesleukin + Guanfacine Moderada
- Amiodarone + Guanfacine Moderada
- Amisulpride + Guanfacine Moderada
- Amobarbital + Guanfacine Moderada
Perguntas frequentes
Can I take Amitriptyline with Guanfacine?
MediHelp rates the interaction as moderate. Amitriptyline and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclics may blunt the antihypertensive effect of centrally acting alpha-2 agonists. Both drugs also cause sedation and may cause orthostatic hypotension or bradycardia.
How serious is the interaction between Amitriptyline and Guanfacine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and adjust guanfacine as required. Monitor for sedation and dizziness.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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