Interações medicamentosas
Clonidine + Guanfacine
Gravidade: Grave
Clonidine and Guanfacine: major interaction.
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Resumo
Both are central alpha-2 adrenergic agonists, so combining them duplicates therapy and increases the risk of hypotension, bradycardia and sedation. Patients with conduction disease may be at greater risk of heart block.
O que esta interação significa em palavras simples
Clonidine and Guanfacine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clonidine belongs to Cardiovascular; Guanfacine belongs to Cardiovascular.
Por que acontece
Additive central alpha-2 agonism reduces sympathetic outflow, causing pharmacodynamic synergism.
O que fazer
Avoid using both together unless there is a clear indication; if used, monitor heart rate, blood pressure and sedation closely. Taper one agent gradually when stopping to avoid rebound hypertension.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Clonidine
- Acebutolol + Clonidine Grave
- Amifostine + Clonidine Grave
- Amiodarone + Clonidine Grave
- Amoxapine + Clonidine Grave
- Atenolol-chlorthalidone + Clonidine Grave
- Atenolol + Clonidine Grave
Outras interações de Guanfacine
- Guanfacine + Lofexidine Grave
- Aldesleukin + Guanfacine Moderada
- Amiodarone + Guanfacine Moderada
- Amisulpride + Guanfacine Moderada
- Amitriptyline + Guanfacine Moderada
- Amobarbital + Guanfacine Moderada
Perguntas frequentes
Can I take Clonidine with Guanfacine?
MediHelp rates the interaction as major. Clonidine and Guanfacine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are central alpha-2 adrenergic agonists, so combining them duplicates therapy and increases the risk of hypotension, bradycardia and sedation. Patients with conduction disease may be at greater risk of heart block.
How serious is the interaction between Clonidine and Guanfacine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both together unless there is a clear indication; if used, monitor heart rate, blood pressure and sedation closely. Taper one agent gradually when stopping to avoid rebound hypertension.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
