Interações medicamentosas
Amitriptyline + Memantine-donepezil
Gravidade: Grave
Amitriptyline and Memantine-donepezil: major interaction.
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Resumo
Amitriptyline has strong anticholinergic activity that directly opposes the cholinergic effect of donepezil, potentially reducing dementia benefit and worsening cognition. Both drugs can also prolong the QT interval.
O que esta interação significa em palavras simples
Amitriptyline and Memantine-donepezil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Memantine-donepezil belongs to Central Nervous System.
Por que acontece
Anticholinergic antagonism of cholinesterase inhibition, plus additive QT prolongation.
O que fazer
Avoid amitriptyline in dementia patients if possible and choose a less anticholinergic alternative. If used, monitor cognition and ECG.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicada
- Memantine-donepezil + Thioridazine Contraindicada
- Amantadine + Memantine-donepezil Grave
- Amiodarone + Memantine-donepezil Grave
- Amisulpride + Memantine-donepezil Grave
- Anagrelide + Memantine-donepezil Grave
Outras interações de Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicada
- Amitriptyline + Methylene blue Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amitriptyline + Pimozide Contraindicada
- Amitriptyline + Procarbazine Contraindicada
- Amitriptyline + Safinamide Contraindicada
Perguntas frequentes
Can I take Amitriptyline with Memantine-donepezil?
MediHelp rates the interaction as major. Amitriptyline and Memantine-donepezil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amitriptyline has strong anticholinergic activity that directly opposes the cholinergic effect of donepezil, potentially reducing dementia benefit and worsening cognition. Both drugs can also prolong the QT interval.
How serious is the interaction between Amitriptyline and Memantine-donepezil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid amitriptyline in dementia patients if possible and choose a less anticholinergic alternative. If used, monitor cognition and ECG.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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