Interações medicamentosas
Memantine-donepezil + Thioridazine
Gravidade: Contraindicada
Memantine-donepezil and Thioridazine: contraindicated interaction.
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Resumo
Donepezil can prolong the QT interval and cause torsades de pointes, and thioridazine is a strongly QT-prolonging antipsychotic. Together the arrhythmia risk is increased. Donepezil-induced bradycardia adds to the risk.
O que esta interação significa em palavras simples
Memantine-donepezil and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Memantine-donepezil belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Por que acontece
Additive QT prolongation, with cholinesterase-inhibitor bradycardia increasing torsades susceptibility.
O que fazer
Avoid the combination; choose a non-QT-prolonging antipsychotic such as low-dose quetiapine if needed, with ECG monitoring.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Memantine-donepezil
Outras interações de Thioridazine
- Abiraterone + Thioridazine Contraindicada
- Adagrasib + Thioridazine Contraindicada
- Amiodarone + Thioridazine Contraindicada
- Amisulpride + Thioridazine Contraindicada
- Amitriptyline + Thioridazine Contraindicada
- Amoxapine + Thioridazine Contraindicada
Perguntas frequentes
Can I take Memantine-donepezil with Thioridazine?
MediHelp rates the interaction as contraindicated. Memantine-donepezil and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Donepezil can prolong the QT interval and cause torsades de pointes, and thioridazine is a strongly QT-prolonging antipsychotic. Together the arrhythmia risk is increased. Donepezil-induced bradycardia adds to the risk.
How serious is the interaction between Memantine-donepezil and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; choose a non-QT-prolonging antipsychotic such as low-dose quetiapine if needed, with ECG monitoring.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Amantadine, Amiodarone. The full list is on the Memantine-donepezil page.
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