Interações medicamentosas
Amitriptyline + Ziprasidone
Gravidade: Contraindicada
Amitriptyline and Ziprasidone: contraindicated interaction.
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Resumo
Both agents prolong the QT interval, so combined use increases the risk of torsades de pointes and sudden cardiac death. Ziprasidone labeling advises against combining it with other QT-prolonging drugs.
O que esta interação significa em palavras simples
Amitriptyline and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amitriptyline belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Por que acontece
Additive QT interval prolongation.
O que fazer
Avoid the combination and choose an antipsychotic or antidepressant with less QT effect. If this cannot be avoided, correct electrolytes and monitor the ECG closely.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Amitriptyline
- Amitriptyline + Isocarboxazid Contraindicada
- Amitriptyline + Methylene blue Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amitriptyline + Pimozide Contraindicada
- Amitriptyline + Procarbazine Contraindicada
- Amitriptyline + Safinamide Contraindicada
Outras interações de Ziprasidone
- Amiodarone + Ziprasidone Contraindicada
- Arsenic trioxide + Ziprasidone Contraindicada
- Bedaquiline + Ziprasidone Contraindicada
- Chloroquine + Ziprasidone Contraindicada
- Citalopram + Ziprasidone Contraindicada
- Clarithromycin + Ziprasidone Contraindicada
Perguntas frequentes
Can I take Amitriptyline with Ziprasidone?
MediHelp rates the interaction as contraindicated. Amitriptyline and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents prolong the QT interval, so combined use increases the risk of torsades de pointes and sudden cardiac death. Ziprasidone labeling advises against combining it with other QT-prolonging drugs.
How serious is the interaction between Amitriptyline and Ziprasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antipsychotic or antidepressant with less QT effect. If this cannot be avoided, correct electrolytes and monitor the ECG closely.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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