Interações medicamentosas
Amlodipine-atorvastatin + Clarithromycin
Gravidade: Grave
Amlodipine-atorvastatin and Clarithromycin: major interaction.
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Clarithromycin strongly inhibits CYP3A4, raising amlodipine and atorvastatin concentrations. This increases the risk of hypotension, edema and acute kidney injury, and of statin-related myopathy or rhabdomyolysis.
O que esta interação significa em palavras simples
Amlodipine-atorvastatin and Clarithromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-atorvastatin belongs to Cardiovascular; Clarithromycin belongs to Anti Bacterial.
Por que acontece
Clarithromycin inhibits CYP3A4 (and P-glycoprotein), reducing metabolism of amlodipine and atorvastatin.
O que fazer
Avoid the combination if possible by using a non-interacting antibiotic such as azithromycin, or suspend atorvastatin during the course. If used, limit the atorvastatin dose and monitor blood pressure and muscle symptoms.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Amlodipine-atorvastatin
Outras interações de Clarithromycin
- Astemizole + Clarithromycin Contraindicada
- Avanafil + Clarithromycin Contraindicada
- Cisapride + Clarithromycin Contraindicada
- Clarithromycin + Colchicine Contraindicada
- Clarithromycin + Conivaptan Contraindicada
- Clarithromycin + Dihydroergotamine Contraindicada
Perguntas frequentes
Can I take Amlodipine-atorvastatin with Clarithromycin?
MediHelp rates the interaction as major. Amlodipine-atorvastatin and Clarithromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin strongly inhibits CYP3A4, raising amlodipine and atorvastatin concentrations. This increases the risk of hypotension, edema and acute kidney injury, and of statin-related myopathy or rhabdomyolysis.
How serious is the interaction between Amlodipine-atorvastatin and Clarithromycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible by using a non-interacting antibiotic such as azithromycin, or suspend atorvastatin during the course. If used, limit the atorvastatin dose and monitor blood pressure and muscle symptoms.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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