Interações medicamentosas
Amlodipine-atorvastatin + Atazanavir
Gravidade: Grave
Amlodipine-atorvastatin and Atazanavir: major interaction.
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Resumo
Atazanavir inhibits CYP3A4 and raises amlodipine exposure, and boosted regimens with ritonavir or cobicistat also raise atorvastatin exposure. This increases the risk of hypotension, edema and statin myopathy.
O que esta interação significa em palavras simples
Amlodipine-atorvastatin and Atazanavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-atorvastatin belongs to Cardiovascular; Atazanavir belongs to Anti Virals.
Por que acontece
Inhibition of CYP3A4 (and OATP with boosters) reduces clearance of amlodipine and atorvastatin.
O que fazer
Use a reduced amlodipine dose, with separate agents, and monitor blood pressure and ECG for PR prolongation. Keep atorvastatin at the lowest effective dose and watch for muscle symptoms.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Amlodipine-atorvastatin
Outras interações de Atazanavir
- Alfuzosin + Atazanavir Contraindicada
- Atazanavir + Avanafil Contraindicada
- Atazanavir + Dronedarone Contraindicada
- Atazanavir + Eletriptan Contraindicada
- Atazanavir + Eplerenone Contraindicada
- Atazanavir + Ergotamine Contraindicada
Perguntas frequentes
Can I take Amlodipine-atorvastatin with Atazanavir?
MediHelp rates the interaction as major. Amlodipine-atorvastatin and Atazanavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir inhibits CYP3A4 and raises amlodipine exposure, and boosted regimens with ritonavir or cobicistat also raise atorvastatin exposure. This increases the risk of hypotension, edema and statin myopathy.
How serious is the interaction between Amlodipine-atorvastatin and Atazanavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reduced amlodipine dose, with separate agents, and monitor blood pressure and ECG for PR prolongation. Keep atorvastatin at the lowest effective dose and watch for muscle symptoms.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Clarithromycin. The full list is on the Amlodipine-atorvastatin page.
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