Interações medicamentosas
Amobarbital + Chlordiazepoxide
Gravidade: Grave
Amobarbital and Chlordiazepoxide: major interaction.
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Resumo
Barbiturates and benzodiazepines together produce marked additive sedation and respiratory depression. Amobarbital also induces hepatic enzymes and may lower chlordiazepoxide exposure over time, making the net effect unpredictable.
O que esta interação significa em palavras simples
Amobarbital and Chlordiazepoxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Chlordiazepoxide belongs to Central Nervous System.
Por que acontece
Additive CNS depression at GABA-A receptors plus CYP3A4 induction by amobarbital, which increases chlordiazepoxide metabolism.
O que fazer
Avoid combining where possible; if needed, use the lowest doses and monitor respiratory rate and level of consciousness. Reassess benzodiazepine dosing when the barbiturate is started or stopped.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Chlordiazepoxide
Outras interações de Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicada
- Amobarbital + Doravirine Contraindicada
- Amobarbital + Elbasvir / grazoprevir Contraindicada
- Amobarbital + Isavuconazonium Contraindicada
- Amobarbital + Isocarboxazid Contraindicada
- Amobarbital + Lonafarnib Contraindicada
Perguntas frequentes
Can I take Amobarbital with Chlordiazepoxide?
MediHelp rates the interaction as major. Amobarbital and Chlordiazepoxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates and benzodiazepines together produce marked additive sedation and respiratory depression. Amobarbital also induces hepatic enzymes and may lower chlordiazepoxide exposure over time, making the net effect unpredictable.
How serious is the interaction between Amobarbital and Chlordiazepoxide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if needed, use the lowest doses and monitor respiratory rate and level of consciousness. Reassess benzodiazepine dosing when the barbiturate is started or stopped.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Atazanavir. The full list is on the Chlordiazepoxide page.
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