Interações medicamentosas
Atazanavir + Chlordiazepoxide
Gravidade: Grave
Atazanavir and Chlordiazepoxide: major interaction.
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Resumo
Atazanavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and may raise chlordiazepoxide and its active metabolites. This can lead to prolonged sedation and respiratory depression.
O que esta interação significa em palavras simples
Atazanavir and Chlordiazepoxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Chlordiazepoxide belongs to Central Nervous System.
Por que acontece
Inhibition of CYP3A4-mediated chlordiazepoxide metabolism.
O que fazer
Use a reduced chlordiazepoxide dose with monitoring for oversedation, or switch to lorazepam or oxazepam.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Chlordiazepoxide
Outras interações de Atazanavir
- Alfuzosin + Atazanavir Contraindicada
- Atazanavir + Avanafil Contraindicada
- Atazanavir + Dronedarone Contraindicada
- Atazanavir + Eletriptan Contraindicada
- Atazanavir + Eplerenone Contraindicada
- Atazanavir + Ergotamine Contraindicada
Perguntas frequentes
Can I take Atazanavir with Chlordiazepoxide?
MediHelp rates the interaction as major. Atazanavir and Chlordiazepoxide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and may raise chlordiazepoxide and its active metabolites. This can lead to prolonged sedation and respiratory depression.
How serious is the interaction between Atazanavir and Chlordiazepoxide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reduced chlordiazepoxide dose with monitoring for oversedation, or switch to lorazepam or oxazepam.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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