Interações medicamentosas
Amobarbital + Isocarboxazid
Gravidade: Contraindicada
Amobarbital and Isocarboxazid: contraindicated interaction.
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Resumo
Isocarboxazid can prolong and intensify the sedative effect of amobarbital by slowing its hepatic breakdown. Profound CNS and respiratory depression may follow.
O que esta interação significa em palavras simples
Amobarbital and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amobarbital belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.
Por que acontece
MAO inhibition and enzyme interference prolong barbiturate effect
O que fazer
Avoid the combination; if a sedative is needed use a non-barbiturate option at reduced dose with monitoring.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicada
- Amobarbital + Doravirine Contraindicada
- Amobarbital + Elbasvir / grazoprevir Contraindicada
- Amobarbital + Isavuconazonium Contraindicada
- Amobarbital + Lonafarnib Contraindicada
- Amobarbital + Lorlatinib Contraindicada
Outras interações de Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicada
- Amitriptyline + Isocarboxazid Contraindicada
- Amoxapine + Isocarboxazid Contraindicada
- Apraclonidine + Isocarboxazid Contraindicada
- Atomoxetine + Isocarboxazid Contraindicada
- Benzphetamine + Isocarboxazid Contraindicada
Perguntas frequentes
Can I take Amobarbital with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Amobarbital and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isocarboxazid can prolong and intensify the sedative effect of amobarbital by slowing its hepatic breakdown. Profound CNS and respiratory depression may follow.
How serious is the interaction between Amobarbital and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if a sedative is needed use a non-barbiturate option at reduced dose with monitoring.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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