Interações medicamentosas
Apraclonidine + Isocarboxazid
Gravidade: Contraindicada
Apraclonidine and Isocarboxazid: contraindicated interaction.
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Resumo
Apraclonidine labeling lists MAO inhibitors as a contraindication. Theoretically, altered catecholamine handling could cause blood pressure changes, although ophthalmic exposure is small.
O que esta interação significa em palavras simples
Apraclonidine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apraclonidine belongs to Cardiovascular; Isocarboxazid belongs to Central Nervous System.
Por que acontece
Mechanism is not firmly established; MAO inhibition may alter catecholamine metabolism and potentiate the systemic effects of the alpha-2 agonist.
O que fazer
Avoid apraclonidine in patients on isocarboxazid and use another intraocular pressure-lowering agent. Follow the labeled contraindication.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicada
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- Amobarbital + Isocarboxazid Contraindicada
- Amoxapine + Isocarboxazid Contraindicada
- Atomoxetine + Isocarboxazid Contraindicada
- Benzphetamine + Isocarboxazid Contraindicada
Outras interações de Apraclonidine
Perguntas frequentes
Can I take Apraclonidine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Apraclonidine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Apraclonidine labeling lists MAO inhibitors as a contraindication. Theoretically, altered catecholamine handling could cause blood pressure changes, although ophthalmic exposure is small.
How serious is the interaction between Apraclonidine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid apraclonidine in patients on isocarboxazid and use another intraocular pressure-lowering agent. Follow the labeled contraindication.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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