Interações medicamentosas
Amphotericin b + Polymyxin b
Gravidade: Grave
Amphotericin b and Polymyxin b: major interaction.
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Both drugs can injure the kidneys, and polymyxin B also has neurotoxic effects. Combined use increases the risk of acute kidney injury and may raise polymyxin exposure.
O que esta interação significa em palavras simples
Amphotericin b and Polymyxin b can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amphotericin b belongs to Anti Fungals; Polymyxin b belongs to Anti Bacterial.
Por que acontece
Additive nephrotoxicity through direct tubular cell injury.
O que fazer
Avoid concomitant use if possible. If both are essential, monitor renal function and electrolytes frequently and keep the patient well hydrated.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Amphotericin b
- Amphotericin b + Cidofovir Contraindicada
- Adefovir + Amphotericin b Grave
- Amikacin + Amphotericin b Grave
- Amphotericin b + Arsenic trioxide Grave
- Amphotericin b + Capreomycin Grave
- Amphotericin b + Cephaloridine Grave
Outras interações de Polymyxin b
- Cidofovir + Polymyxin b Contraindicada
- Colistin + Polymyxin b Contraindicada
- Acyclovir + Polymyxin b Grave
- Adefovir + Polymyxin b Grave
- Amikacin + Polymyxin b Grave
- Atracurium + Polymyxin b Grave
Perguntas frequentes
Can I take Amphotericin b with Polymyxin b?
MediHelp rates the interaction as major. Amphotericin b and Polymyxin b can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can injure the kidneys, and polymyxin B also has neurotoxic effects. Combined use increases the risk of acute kidney injury and may raise polymyxin exposure.
How serious is the interaction between Amphotericin b and Polymyxin b?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use if possible. If both are essential, monitor renal function and electrolytes frequently and keep the patient well hydrated.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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