Interações medicamentosas
Atracurium + Polymyxin b
Gravidade: Grave
Atracurium and Polymyxin b: major interaction.
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Resumo
Parenteral polymyxin B has neuromuscular blocking activity and can potentiate nondepolarizing blockers, producing prolonged paralysis and respiratory failure. The effect may be resistant to reversal with anticholinesterases.
O que esta interação significa em palavras simples
Atracurium and Polymyxin b can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atracurium belongs to Musculoskeletal; Polymyxin b belongs to Anti Bacterial.
Por que acontece
Polymyxin B impairs neuromuscular transmission through pre- and postsynaptic effects, adding to atracurium blockade.
O que fazer
Avoid concurrent use when possible; otherwise lower atracurium doses, monitor with train-of-four and keep ventilatory support available. Check calcium levels.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Atracurium
Outras interações de Polymyxin b
- Cidofovir + Polymyxin b Contraindicada
- Colistin + Polymyxin b Contraindicada
- Acyclovir + Polymyxin b Grave
- Adefovir + Polymyxin b Grave
- Amikacin + Polymyxin b Grave
- Amphotericin b + Polymyxin b Grave
Perguntas frequentes
Can I take Atracurium with Polymyxin b?
MediHelp rates the interaction as major. Atracurium and Polymyxin b can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Parenteral polymyxin B has neuromuscular blocking activity and can potentiate nondepolarizing blockers, producing prolonged paralysis and respiratory failure. The effect may be resistant to reversal with anticholinesterases.
How serious is the interaction between Atracurium and Polymyxin b?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use when possible; otherwise lower atracurium doses, monitor with train-of-four and keep ventilatory support available. Check calcium levels.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen. The full list is on the Atracurium page.
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