Interações medicamentosas
Amphotericin b + Streptomycin
Gravidade: Grave
Amphotericin b and Streptomycin: major interaction.
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Resumo
Both drugs are nephrotoxic, and streptomycin is also ototoxic and vestibulotoxic. Combined use increases the risk of kidney injury, which can further raise aminoglycoside levels and toxicity.
O que esta interação significa em palavras simples
Amphotericin b and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amphotericin b belongs to Anti Fungals; Streptomycin belongs to Anti Bacterial.
Por que acontece
Additive nephrotoxicity with reduced aminoglycoside clearance, increasing ototoxicity risk.
O que fazer
Avoid concurrent use if possible; otherwise monitor renal function and streptomycin levels and assess hearing and balance. Ensure adequate hydration.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Amphotericin b
- Amphotericin b + Cidofovir Contraindicada
- Adefovir + Amphotericin b Grave
- Amikacin + Amphotericin b Grave
- Amphotericin b + Arsenic trioxide Grave
- Amphotericin b + Capreomycin Grave
- Amphotericin b + Cephaloridine Grave
Outras interações de Streptomycin
Perguntas frequentes
Can I take Amphotericin b with Streptomycin?
MediHelp rates the interaction as major. Amphotericin b and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and streptomycin is also ototoxic and vestibulotoxic. Combined use increases the risk of kidney injury, which can further raise aminoglycoside levels and toxicity.
How serious is the interaction between Amphotericin b and Streptomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if possible; otherwise monitor renal function and streptomycin levels and assess hearing and balance. Ensure adequate hydration.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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