Interações medicamentosas
Amphotericin b deoxycholate + Streptomycin
Gravidade: Grave
Amphotericin b deoxycholate and Streptomycin: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Both drugs are nephrotoxic, and streptomycin is also ototoxic and vestibulotoxic. Used together, they can cause additive kidney injury, and reduced renal clearance of streptomycin can in turn raise its levels and increase ear toxicity.
O que esta interação significa em palavras simples
Amphotericin b deoxycholate and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive nephrotoxicity, with impaired renal function increasing aminoglycoside accumulation and ototoxicity.
O que fazer
Avoid the combination when alternatives exist. If needed, monitor serum creatinine, electrolytes and streptomycin levels, and assess hearing and vestibular function.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Streptomycin
Perguntas frequentes
Can I take Amphotericin b deoxycholate with Streptomycin?
MediHelp rates the interaction as major. Amphotericin b deoxycholate and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and streptomycin is also ototoxic and vestibulotoxic. Used together, they can cause additive kidney injury, and reduced renal clearance of streptomycin can in turn raise its levels and increase ear toxicity.
How serious is the interaction between Amphotericin b deoxycholate and Streptomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when alternatives exist. If needed, monitor serum creatinine, electrolytes and streptomycin levels, and assess hearing and vestibular function.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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