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Interações medicamentosas

Anti-thymocyte + Bcg vaccine live

Gravidade: Contraindicada

Anti-thymocyte and Bcg vaccine live: contraindicated interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

O conteúdo clínico desta página está disponível apenas em inglês.

Resumo

Anti-thymocyte globulin causes profound T-cell depletion, so a live attenuated vaccine may cause disseminated infection. The vaccine is also likely to be ineffective in this setting.

O que esta interação significa em palavras simples

Anti-thymocyte and Bcg vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Nível de evidência: High

Por que acontece

Profound T-cell immunosuppression allows uncontrolled replication of live attenuated BCG.

O que fazer

Do not give BCG during or after anti-thymocyte globulin until immune recovery is confirmed by the specialist team. Give it at least several weeks before starting immunosuppression when feasible.

O que perguntar ao farmacêutico

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

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Perguntas frequentes

Can I take Anti-thymocyte with Bcg vaccine live?

MediHelp rates the interaction as contraindicated. Anti-thymocyte and Bcg vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Anti-thymocyte globulin causes profound T-cell depletion, so a live attenuated vaccine may cause disseminated infection. The vaccine is also likely to be ineffective in this setting.

How serious is the interaction between Anti-thymocyte and Bcg vaccine live?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give BCG during or after anti-thymocyte globulin until immune recovery is confirmed by the specialist team. Give it at least several weeks before starting immunosuppression when feasible.

What other medicines interact with Anti-thymocyte?

MediHelp also lists interactions of Anti-thymocyte with, for example, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Anti-thymocyte page.

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