Drug interactions
Anti-thymocyte + Bcg vaccine live
Severity: Contraindicated
Anti-thymocyte and Bcg vaccine live: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anti-thymocyte globulin causes profound T-cell depletion, so a live attenuated vaccine may cause disseminated infection. The vaccine is also likely to be ineffective in this setting.
What this interaction means in plain words
Anti-thymocyte and Bcg vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Profound T-cell immunosuppression allows uncontrolled replication of live attenuated BCG.
What to do
Do not give BCG during or after anti-thymocyte globulin until immune recovery is confirmed by the specialist team. Give it at least several weeks before starting immunosuppression when feasible.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Anti-thymocyte
- Anti-thymocyte + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Anti-thymocyte + Measles mumps and rubella vaccine live Contraindicated
- Anti-thymocyte + Measles mumps rubella and varicella vaccine live Contraindicated
- Anti-thymocyte + Measles vaccine Contraindicated
- Anti-thymocyte + Rotavirus oral vaccine live Contraindicated
- Anti-thymocyte + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Anti-thymocyte with Bcg vaccine live?
MediHelp rates the interaction as contraindicated. Anti-thymocyte and Bcg vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Anti-thymocyte globulin causes profound T-cell depletion, so a live attenuated vaccine may cause disseminated infection. The vaccine is also likely to be ineffective in this setting.
How serious is the interaction between Anti-thymocyte and Bcg vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give BCG during or after anti-thymocyte globulin until immune recovery is confirmed by the specialist team. Give it at least several weeks before starting immunosuppression when feasible.
What other medicines interact with Anti-thymocyte?
MediHelp also lists interactions of Anti-thymocyte with, for example, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Anti-thymocyte page.
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