Interações medicamentosas
Antipsychotics (e.g., haloperidol) + Metoclopramide
Gravidade: Grave
Antipsychotics (e.g., haloperidol) and Metoclopramide: major interaction.
Última atualização Fontes: US FDA label
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Resumo
Combining metoclopramide with antipsychotics increases the risk of extrapyramidal symptoms, including acute dystonia, parkinsonism, akathisia and tardive dyskinesia, and may raise neuroleptic malignant syndrome risk. Metoclopramide labeling warns against use with other dopamine antagonists. Older adults and long-term users are most at risk.
O que esta interação significa em palavras simples
Antipsychotics (e.g., haloperidol) and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive central dopamine D2 receptor antagonism in the nigrostriatal pathway.
O que fazer
Avoid the combination; use a non-dopamine-blocking antiemetic such as ondansetron (checking QT risk) or a prokinetic alternative. If unavoidable, restrict metoclopramide to short courses (under 5 days) and monitor for movement disorders.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Metoclopramide
Perguntas frequentes
Can I take Antipsychotics (e.g., haloperidol) with Metoclopramide?
MediHelp rates the interaction as major. Antipsychotics (e.g., haloperidol) and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining metoclopramide with antipsychotics increases the risk of extrapyramidal symptoms, including acute dystonia, parkinsonism, akathisia and tardive dyskinesia, and may raise neuroleptic malignant syndrome risk. Metoclopramide labeling warns against use with other dopamine antagonists. Older adults and long-term users are most at risk.
How serious is the interaction between Antipsychotics (e.g., haloperidol) and Metoclopramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use a non-dopamine-blocking antiemetic such as ondansetron (checking QT risk) or a prokinetic alternative. If unavoidable, restrict metoclopramide to short courses (under 5 days) and monitor for movement disorders.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Apomorphine. The full list is on the Metoclopramide page.
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