Interações medicamentosas
Aripiprazole + Metoclopramide
Gravidade: Grave
Aripiprazole and Metoclopramide: major interaction.
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Resumo
Both drugs block dopamine D2 receptors, so combined use increases the risk of extrapyramidal symptoms, tardive dyskinesia and rarely neuroleptic malignant syndrome. Aripiprazole is a partial agonist, but the risk remains.
O que esta interação significa em palavras simples
Aripiprazole and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aripiprazole belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Por que acontece
Additive central dopamine D2 receptor antagonism.
O que fazer
Avoid combining where possible and choose an antiemetic without central dopamine antagonism, such as ondansetron. If unavoidable, use the shortest course and monitor for movement disorders and fever with rigidity.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Metoclopramide
Outras interações de Aripiprazole
- Aripiprazole + Pimozide Contraindicada
- Aripiprazole + Thioridazine Contraindicada
- Amisulpride + Aripiprazole Grave
- Aripiprazole + Arsenic trioxide Grave
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Grave
- Aripiprazole + Carbamazepine Grave
Perguntas frequentes
Can I take Aripiprazole with Metoclopramide?
MediHelp rates the interaction as major. Aripiprazole and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs block dopamine D2 receptors, so combined use increases the risk of extrapyramidal symptoms, tardive dyskinesia and rarely neuroleptic malignant syndrome. Aripiprazole is a partial agonist, but the risk remains.
How serious is the interaction between Aripiprazole and Metoclopramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible and choose an antiemetic without central dopamine antagonism, such as ondansetron. If unavoidable, use the shortest course and monitor for movement disorders and fever with rigidity.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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