Interações medicamentosas
Apalutamide + Flutamide
Gravidade: Moderada
Apalutamide and Flutamide: moderate interaction.
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Resumo
Flutamide is converted by CYP1A2 to its active metabolite, with some CYP3A4 involvement. Apalutamide as an inducer may alter exposure, and both drugs are antiandrogens with additive hepatotoxicity potential, and combining them has no therapeutic rationale.
O que esta interação significa em palavras simples
Apalutamide and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Flutamide belongs to Endocrine.
Por que acontece
Apalutamide induces CYP3A4 and may change flutamide metabolism, with overlapping antiandrogen pharmacology.
O que fazer
Avoid using two antiandrogens together. If they must be combined, monitor liver tests and clinical response.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Flutamide
Outras interações de Apalutamide
- Apalutamide + Cabotegravir Contraindicada
- Apalutamide + Cobicistat Contraindicada
- Apalutamide + Doravirine Contraindicada
- Apalutamide + Elbasvir / grazoprevir Contraindicada
- Apalutamide + Ensitrelvir Contraindicada
- Apalutamide + Fostemsavir Contraindicada
Perguntas frequentes
Can I take Apalutamide with Flutamide?
MediHelp rates the interaction as moderate. Apalutamide and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flutamide is converted by CYP1A2 to its active metabolite, with some CYP3A4 involvement. Apalutamide as an inducer may alter exposure, and both drugs are antiandrogens with additive hepatotoxicity potential, and combining them has no therapeutic rationale.
How serious is the interaction between Apalutamide and Flutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two antiandrogens together. If they must be combined, monitor liver tests and clinical response.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
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