Interações medicamentosas
Flutamide + Pexidartinib
Gravidade: Grave
Flutamide and Pexidartinib: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Both flutamide and pexidartinib can cause serious liver injury, and combined use may increase the risk of severe hepatotoxicity. Pexidartinib is restricted through a risk program because of cholestatic liver injury.
O que esta interação significa em palavras simples
Flutamide and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flutamide belongs to Endocrine; Pexidartinib belongs to Oncology.
Por que acontece
Additive hepatotoxicity from two hepatotoxic drugs.
O que fazer
Avoid combining them. If unavoidable, monitor liver tests closely and stop treatment at signs of liver injury.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Flutamide
- Flutamide + Idelalisib Grave
- Flutamide + Levoketoconazole Grave
- Flutamide + Pretomanid Grave
- Flutamide + Valoctocogene roxaparvovec Grave
- Apalutamide + Flutamide Moderada
- Bupivacaine implant + Flutamide Moderada
Outras interações de Pexidartinib
Perguntas frequentes
Can I take Flutamide with Pexidartinib?
MediHelp rates the interaction as major. Flutamide and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both flutamide and pexidartinib can cause serious liver injury, and combined use may increase the risk of severe hepatotoxicity. Pexidartinib is restricted through a risk program because of cholestatic liver injury.
How serious is the interaction between Flutamide and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining them. If unavoidable, monitor liver tests closely and stop treatment at signs of liver injury.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pretomanid. The full list is on the Flutamide page.
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