Interações medicamentosas
Flutamide + Idelalisib
Gravidade: Grave
Flutamide and Idelalisib: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Idelalisib is a strong CYP3A inhibitor and may raise flutamide exposure. Both drugs carry a risk of serious hepatotoxicity, so the combination may increase liver injury risk.
O que esta interação significa em palavras simples
Flutamide and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flutamide belongs to Endocrine; Idelalisib belongs to Oncology.
Por que acontece
CYP3A4 inhibition by idelalisib reduces flutamide metabolism, compounded by additive hepatotoxicity.
O que fazer
Avoid the combination where possible. If used, monitor liver enzymes frequently and stop either drug if significant elevation occurs.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Flutamide e Idelalisib, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Outras interações de Flutamide
- Flutamide + Levoketoconazole Grave
- Flutamide + Pexidartinib Grave
- Flutamide + Pretomanid Grave
- Flutamide + Valoctocogene roxaparvovec Grave
- Apalutamide + Flutamide Moderada
- Bupivacaine implant + Flutamide Moderada
Outras interações de Idelalisib
- Alfuzosin + Idelalisib Contraindicada
- Cisapride + Idelalisib Contraindicada
- Dihydroergotamine + Idelalisib Contraindicada
- Dronedarone + Idelalisib Contraindicada
- Eletriptan + Idelalisib Contraindicada
- Eplerenone + Idelalisib Contraindicada
Perguntas frequentes
Can I take Flutamide with Idelalisib?
MediHelp rates the interaction as major. Flutamide and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A inhibitor and may raise flutamide exposure. Both drugs carry a risk of serious hepatotoxicity, so the combination may increase liver injury risk.
How serious is the interaction between Flutamide and Idelalisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, monitor liver enzymes frequently and stop either drug if significant elevation occurs.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Levoketoconazole, Pexidartinib, Pretomanid. The full list is on the Flutamide page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
