Interações medicamentosas
Apixaban + Celecoxib
Gravidade: Grave
Apixaban and Celecoxib: major interaction.
Última atualização
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Resumo
Celecoxib has less antiplatelet effect than nonselective NSAIDs but can still cause gastrointestinal mucosal injury, and apixaban adds anticoagulation. The combination increases the risk of clinically significant bleeding.
O que esta interação significa em palavras simples
Apixaban and Celecoxib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apixaban belongs to Cardiovascular; Celecoxib belongs to Musculoskeletal.
Por que acontece
Additive bleeding risk from NSAID mucosal injury and factor Xa inhibition.
O que fazer
Avoid if possible and use paracetamol for pain. If celecoxib is required, give the lowest dose for the shortest time with gastroprotection and monitor for bleeding.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Celecoxib
- Celecoxib + Ketorolac Contraindicada
- Celecoxib + Ketorolac intranasal Contraindicada
- Aceclofenac + Celecoxib Grave
- Acemetacin + Celecoxib Grave
- Amiloride + Celecoxib Grave
- Betrixaban + Celecoxib Grave
Outras interações de Apixaban
- Apixaban + Dabigatran Contraindicada
- Apixaban + Defibrotide Contraindicada
- Apixaban + Edoxaban Contraindicada
- Apixaban + Ketorolac Contraindicada
- Apixaban + Mifepristone Contraindicada
- Abciximab + Apixaban Grave
Perguntas frequentes
Can I take Apixaban with Celecoxib?
MediHelp rates the interaction as major. Apixaban and Celecoxib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Celecoxib has less antiplatelet effect than nonselective NSAIDs but can still cause gastrointestinal mucosal injury, and apixaban adds anticoagulation. The combination increases the risk of clinically significant bleeding.
How serious is the interaction between Apixaban and Celecoxib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and use paracetamol for pain. If celecoxib is required, give the lowest dose for the shortest time with gastroprotection and monitor for bleeding.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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