Interações medicamentosas
Apomorphine + Palonosetron
Gravidade: Contraindicada
Apomorphine and Palonosetron: contraindicated interaction.
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Resumo
Profound hypotension and loss of consciousness have been reported when 5-HT3 antagonists are given with apomorphine. The combination is therefore avoided as a class.
O que esta interação significa em palavras simples
Apomorphine and Palonosetron are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apomorphine belongs to Central Nervous System; Palonosetron belongs to Gastrointestinal Tract.
Por que acontece
Mechanism is not established.
O que fazer
Do not combine. Choose a non-5-HT3 antiemetic such as domperidone or trimethobenzamide.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Palonosetron
- Isocarboxazid + Palonosetron Grave
- Palonosetron + Phenelzine Grave
- Palonosetron + Tranylcypromine Grave
- Almotriptan + Palonosetron Moderada
- Amitriptyline + Palonosetron Moderada
- Amoxapine + Palonosetron Moderada
Outras interações de Apomorphine
- Alosetron + Apomorphine Contraindicada
- Apomorphine + Cisapride Contraindicada
- Apomorphine + Dolasetron Contraindicada
- Apomorphine + Granisetron Contraindicada
- Apomorphine + Netupitant-palonosetron Contraindicada
- Apomorphine + Ondansetron Contraindicada
Perguntas frequentes
Can I take Apomorphine with Palonosetron?
MediHelp rates the interaction as contraindicated. Apomorphine and Palonosetron are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Profound hypotension and loss of consciousness have been reported when 5-HT3 antagonists are given with apomorphine. The combination is therefore avoided as a class.
How serious is the interaction between Apomorphine and Palonosetron?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Choose a non-5-HT3 antiemetic such as domperidone or trimethobenzamide.
What other medicines interact with Palonosetron?
MediHelp also lists interactions of Palonosetron with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Palonosetron page.
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