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Interações medicamentosas

Apomorphine + Ondansetron

Gravidade: Contraindicada

Apomorphine and Ondansetron: contraindicated interaction.

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Resumo

Profound hypotension and loss of consciousness have been reported when ondansetron is given with apomorphine. Both can also prolong the QT interval.

O que esta interação significa em palavras simples

Apomorphine and Ondansetron are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Apomorphine belongs to Central Nervous System; Ondansetron belongs to Gastrointestinal Tract.

Nível de evidência: Moderate

Por que acontece

Mechanism of the hypotension is not established; additive QT prolongation is also possible.

O que fazer

Do not combine. Use a non-5-HT3 antiemetic such as domperidone or trimethobenzamide with apomorphine, according to local availability.

O que perguntar ao farmacêutico

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

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Perguntas frequentes

Can I take Apomorphine with Ondansetron?

MediHelp rates the interaction as contraindicated. Apomorphine and Ondansetron are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Profound hypotension and loss of consciousness have been reported when ondansetron is given with apomorphine. Both can also prolong the QT interval.

How serious is the interaction between Apomorphine and Ondansetron?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use a non-5-HT3 antiemetic such as domperidone or trimethobenzamide with apomorphine, according to local availability.

What other medicines interact with Ondansetron?

MediHelp also lists interactions of Ondansetron with, for example, Thioridazine, Vandetanib, Adagrasib. The full list is on the Ondansetron page.

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