Interações medicamentosas
Apomorphine + Netupitant-palonosetron
Gravidade: Contraindicada
Apomorphine and Netupitant-palonosetron: contraindicated interaction.
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Resumo
Profound hypotension and loss of consciousness have been reported when apomorphine is given with ondansetron, and the apomorphine label contraindicates 5-HT3 antagonists. Palonosetron is a related 5-HT3 antagonist, so the same risk is assumed by class.
O que esta interação significa em palavras simples
Apomorphine and Netupitant-palonosetron are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apomorphine belongs to Central Nervous System; Netupitant-palonosetron belongs to Gastrointestinal Tract.
Por que acontece
The mechanism is not established; it is thought to involve a pharmacodynamic effect of 5-HT3 antagonism on apomorphine-related hypotension.
O que fazer
Avoid combining apomorphine with 5-HT3 antagonists. Use an antiemetic such as trimethobenzamide for apomorphine-related nausea.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Netupitant-palonosetron
Outras interações de Apomorphine
- Alosetron + Apomorphine Contraindicada
- Apomorphine + Cisapride Contraindicada
- Apomorphine + Dolasetron Contraindicada
- Apomorphine + Granisetron Contraindicada
- Apomorphine + Ondansetron Contraindicada
- Apomorphine + Palonosetron Contraindicada
Perguntas frequentes
Can I take Apomorphine with Netupitant-palonosetron?
MediHelp rates the interaction as contraindicated. Apomorphine and Netupitant-palonosetron are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Profound hypotension and loss of consciousness have been reported when apomorphine is given with ondansetron, and the apomorphine label contraindicates 5-HT3 antagonists. Palonosetron is a related 5-HT3 antagonist, so the same risk is assumed by class.
How serious is the interaction between Apomorphine and Netupitant-palonosetron?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining apomorphine with 5-HT3 antagonists. Use an antiemetic such as trimethobenzamide for apomorphine-related nausea.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Flibanserin, Apalutamide, Avapritinib. The full list is on the Netupitant-palonosetron page.
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