Interações medicamentosas
Arformoterol + Timolol
Gravidade: Grave
Arformoterol and Timolol: major interaction.
Última atualização Fontes: UK SmPC
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Timolol blocks beta-2 receptors and can reduce or abolish the bronchodilator effect of arformoterol. It may precipitate bronchospasm in patients with reactive airway disease.
O que esta interação significa em palavras simples
Arformoterol and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Arformoterol belongs to Respiratory; Timolol belongs to Cardiovascular.
Por que acontece
Competitive antagonism at beta-2 adrenergic receptors by timolol opposes the agonist effect of arformoterol.
O que fazer
Avoid combining nonselective beta-blockers with arformoterol in patients with asthma or COPD. If a beta-blocker is required, choose a cardioselective one and monitor respiratory status.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Timolol
- Acebutolol + Timolol Grave
- Albuterol + Timolol Grave
- Aldesleukin + Timolol Grave
- Amifostine + Timolol Grave
- Amiodarone + Timolol Grave
- Atenolol-chlorthalidone + Timolol Grave
Outras interações de Arformoterol
Perguntas frequentes
Can I take Arformoterol with Timolol?
MediHelp rates the interaction as major. Arformoterol and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Timolol blocks beta-2 receptors and can reduce or abolish the bronchodilator effect of arformoterol. It may precipitate bronchospasm in patients with reactive airway disease.
How serious is the interaction between Arformoterol and Timolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining nonselective beta-blockers with arformoterol in patients with asthma or COPD. If a beta-blocker is required, choose a cardioselective one and monitor respiratory status.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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