Interações medicamentosas
Artemether / lumefantrine + Ofloxacin
Gravidade: Grave
Artemether / lumefantrine and Ofloxacin: major interaction.
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Resumo
Artemether/lumefantrine and ofloxacin each prolong the QT interval, so combined use increases the risk of serious ventricular arrhythmias. The labeling of artemether/lumefantrine advises caution with other QT-prolonging drugs.
O que esta interação significa em palavras simples
Artemether / lumefantrine and Ofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive hERG potassium channel blockade leading to QT prolongation.
O que fazer
Avoid the combination if an alternative exists. If it is unavoidable, obtain an ECG and correct potassium and magnesium before and during treatment.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Ofloxacin
- Ofloxacin + Thioridazine Contraindicada
- Adagrasib + Ofloxacin Grave
- Amiodarone + Ofloxacin Grave
- Amisulpride + Ofloxacin Grave
- Anagrelide + Ofloxacin Grave
- Arsenic trioxide + Ofloxacin Grave
Perguntas frequentes
Can I take Artemether / lumefantrine with Ofloxacin?
MediHelp rates the interaction as major. Artemether / lumefantrine and Ofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Artemether/lumefantrine and ofloxacin each prolong the QT interval, so combined use increases the risk of serious ventricular arrhythmias. The labeling of artemether/lumefantrine advises caution with other QT-prolonging drugs.
How serious is the interaction between Artemether / lumefantrine and Ofloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative exists. If it is unavoidable, obtain an ECG and correct potassium and magnesium before and during treatment.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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