Interações medicamentosas
Arsenic trioxide + Ofloxacin
Gravidade: Grave
Arsenic trioxide and Ofloxacin: major interaction.
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Resumo
Arsenic trioxide causes marked QT prolongation and torsades de pointes, and ofloxacin adds further risk. Together they may precipitate life-threatening ventricular arrhythmia.
O que esta interação significa em palavras simples
Arsenic trioxide and Ofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Arsenic trioxide belongs to Oncology; Ofloxacin belongs to Anti Bacterial.
Por que acontece
Additive QT prolongation; arsenic trioxide alters cardiac ion currents and ofloxacin blocks hERG potassium channels.
O que fazer
Avoid the combination and choose a non-QT-prolonging antibiotic. If unavoidable, monitor ECG and keep potassium and magnesium within normal range.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Ofloxacin
- Ofloxacin + Thioridazine Contraindicada
- Adagrasib + Ofloxacin Grave
- Amiodarone + Ofloxacin Grave
- Amisulpride + Ofloxacin Grave
- Anagrelide + Ofloxacin Grave
- Artemether / lumefantrine + Ofloxacin Grave
Outras interações de Arsenic trioxide
- Amiodarone + Arsenic trioxide Contraindicada
- Amisulpride + Arsenic trioxide Contraindicada
- Arsenic trioxide + Clomipramine Contraindicada
- Arsenic trioxide + Dronedarone Contraindicada
- Arsenic trioxide + Fluphenazine Contraindicada
- Arsenic trioxide + Gemifloxacin Contraindicada
Perguntas frequentes
Can I take Arsenic trioxide with Ofloxacin?
MediHelp rates the interaction as major. Arsenic trioxide and Ofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Arsenic trioxide causes marked QT prolongation and torsades de pointes, and ofloxacin adds further risk. Together they may precipitate life-threatening ventricular arrhythmia.
How serious is the interaction between Arsenic trioxide and Ofloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-QT-prolonging antibiotic. If unavoidable, monitor ECG and keep potassium and magnesium within normal range.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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