Interações medicamentosas
Ofloxacin + Thioridazine
Gravidade: Contraindicada
Ofloxacin and Thioridazine: contraindicated interaction.
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Resumo
Thioridazine causes marked, dose-related QT prolongation and carries a boxed warning against co-use with other QT-prolonging drugs. Adding ofloxacin further increases the risk of torsades de pointes and sudden cardiac death.
O que esta interação significa em palavras simples
Ofloxacin and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ofloxacin belongs to Anti Bacterial; Thioridazine belongs to Central Nervous System.
Por que acontece
Additive blockade of cardiac potassium channels on top of the strong QT-prolonging effect of thioridazine.
O que fazer
Avoid the combination and select an antibiotic without QT effects. If the antibiotic cannot be changed, withhold thioridazine under specialist guidance.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Ofloxacin
Outras interações de Thioridazine
- Abiraterone + Thioridazine Contraindicada
- Adagrasib + Thioridazine Contraindicada
- Amiodarone + Thioridazine Contraindicada
- Amisulpride + Thioridazine Contraindicada
- Amitriptyline + Thioridazine Contraindicada
- Amoxapine + Thioridazine Contraindicada
Perguntas frequentes
Can I take Ofloxacin with Thioridazine?
MediHelp rates the interaction as contraindicated. Ofloxacin and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine causes marked, dose-related QT prolongation and carries a boxed warning against co-use with other QT-prolonging drugs. Adding ofloxacin further increases the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Ofloxacin and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and select an antibiotic without QT effects. If the antibiotic cannot be changed, withhold thioridazine under specialist guidance.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Ofloxacin page.
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