Interações medicamentosas
Atazanavir + Bosentan
Gravidade: Grave
Atazanavir and Bosentan: major interaction.
Última atualização Fontes: US FDA label
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Resumo
Atazanavir inhibits CYP3A4 and raises bosentan concentrations substantially, increasing the risk of hepatotoxicity, edema and hypotension. Bosentan may also lower unboosted atazanavir concentrations.
O que esta interação significa em palavras simples
Atazanavir and Bosentan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Bosentan belongs to Miscellaneous.
Por que acontece
CYP3A4 inhibition by atazanavir reduces bosentan clearance, while bosentan induction may lower atazanavir levels.
O que fazer
If coadministered, start bosentan at a reduced dose or frequency in patients already stable on a boosted protease inhibitor, and monitor liver tests and blood pressure. Use ritonavir-boosted atazanavir rather than unboosted atazanavir.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Bosentan
- Bosentan + Cyclosporin Contraindicada
- Bosentan + Glibenclamide Contraindicada
- Bosentan + Glyburide-metformin Contraindicada
- Bosentan + Lonafarnib Contraindicada
- Bosentan + Sparsentan Contraindicada
- Artemether / lumefantrine + Bosentan Grave
Outras interações de Atazanavir
- Alfuzosin + Atazanavir Contraindicada
- Atazanavir + Avanafil Contraindicada
- Atazanavir + Dronedarone Contraindicada
- Atazanavir + Eletriptan Contraindicada
- Atazanavir + Eplerenone Contraindicada
- Atazanavir + Ergotamine Contraindicada
Perguntas frequentes
Can I take Atazanavir with Bosentan?
MediHelp rates the interaction as major. Atazanavir and Bosentan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir inhibits CYP3A4 and raises bosentan concentrations substantially, increasing the risk of hepatotoxicity, edema and hypotension. Bosentan may also lower unboosted atazanavir concentrations.
How serious is the interaction between Atazanavir and Bosentan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If coadministered, start bosentan at a reduced dose or frequency in patients already stable on a boosted protease inhibitor, and monitor liver tests and blood pressure. Use ritonavir-boosted atazanavir rather than unboosted atazanavir.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glibenclamide, Glyburide-metformin. The full list is on the Bosentan page.
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